Immune human lymphocytes produce an acid-labile α-interferon
نویسندگان
چکیده
We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of alpha-IFN and physicochemical properties of gamma-IFN. This IFN is produced by normal peripheral blood mononuclear cells during an immune response but has also been associated with autoimmune disease (10). The system described here will be useful in elucidating the biological significance and cell of origin of this IFN.
منابع مشابه
Rat leukocyte interferons: production of an acid-labile interferon after induction with Newcastle disease virus.
Rat leukocytes produce three interferon species after infection with Newcastle disease virus. Two of the three interferon species (22-24,000 and 30,000 daltons) were acid and heat stable, protected rat and mouse cells from virus-mediated cytopathic effect (CPE), and were neutralized by antisera to mouse L-cell (alpha/beta) interferon. The third, 30,000-dalton interferon species was heat and aci...
متن کاملImmune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus
Influenza virus stimulation of human lymphocytes induced high levels of immune interferon in lymphocyte cultures. The lymphocytes of normal adults produced approximately 1,000 U/10(6) cells, which was in large part gamma interferon. The lymphocytes of individuals recently vaccinated yielded very high levels (10-50,000 U/10(6) cells) of interferon. The interferon was pH 2 labile, and was not neu...
متن کاملAssessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats
Background and Objectives: Surgery via different mechanisms causes immunosuppression in the post-operative period. The aim of the present study was to investigate the effects of preoperative administration of cyclooxygenase inhibitors on blood levels of Interleukin-2 (IL-2), Interferon-γ (IFN-γ), Tumor Necrosis Factor-α (TNF-α), white blood cells (WBCs) and lymphocytes. Methods: Seventy-five ma...
متن کاملImmunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People
Background: Aging is associated with attenuation of immune responses. Studies show that old people are vulnerable to infectious diseases such as influenza. α-Tocopherol as an immunomodulator affects immune responses. In the present study, the effect of α-tocopherol, on lymphocyte responses i.e. interferon-gamma (IFN-γ), Tumor Necrosis Factor-alpha (TNF-α), and nuclear factor-κB (NF-κB) in elde...
متن کاملEffect of Corynebacterium parvum on human T-lymphocyte interferon production and T-lymphocyte proliferation in vitro.
Heat-killed, preservatIve-free preparations of strain CN 6134 Cosynebacterlum parvum have been demonstrated to Induceinterferonin culturesof normaladufthuman1lymphocytes.C. parvumwas also shownto inducehuman T-lymphocytes to proliferate In vitro. The maximum inter feron and proliferative response was observed 7 days after initiationof cultureat a finalC. parvumconcentration of 140 @&g/mb. Human...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 157 شماره
صفحات -
تاریخ انتشار 1983